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TRAIL-R2 (DR5) Mouse anti-Human, Clone: DR5-01-1, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119416

Catalog No. 01-676-163


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Description

Description

This antibody recognizes an extracellular domain of TRAIL-R2 (DR5). A suggested positive control for this product is Jurkat human peripheral blood leukemia T cells.

DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a recently identified death domain containing receptor for TRAIL, which mediates TRAIL induced apoptosis. DR5 is a member of the TNF-receptor superfamily, and contains an intracellular death domain. DR5 can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by DR5. Two transcript variants encoding different isoforms of DR5 and one non-coding transcript have been found. Overexpression of DR5 induces apoptosis and activates NF-kappa-B. DR5 is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. Diseases associated with DR5 dysfunction include squamous cell carcinoma, and diffuse infiltrative lymphocytosis syndrome.
Specifications

Specifications

TRAIL-R2 (DR5)
Monoclonal
1 mg/mL
PBS with 15mM sodium azide; pH 7.4
O14763
CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9, Trail receptor 2
Mouse
IgG1
100 μg
4° C, do not freeze
Primary
8795
Flow Cytometry
DR5-01-1
Unconjugated
TNFRSF10B
Liquid
TNFRSF10B
Recombit fusion protein of human IgG heavy chain and extracellular domain of DR5.
Protein A
RUO
Antibody
Monoclonal
Human
Documents
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