TXNIP Rabbit anti-Human, Non-human primate, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523485

Catalog No. PIPA523485

Description

Thioredoxin-interacting protein belongs to the arrestin family. It acts as an oxidative stress mediator by inhibiting thioredoxin activity or by inhibiting thioredoxin activity or by limiting its bioavailability. It functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. It is required for the maturation of natural killer cells. Recently reported, TXNIP deficiency led to the impairment of NLRP3 inflammasome activation to innate immune responses and reduced secretion of interleukin IL-1ß.

Specifications

• Antigen: TxNIP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TXNIP
• Format: Liquid
• Gene Symbols: TXNIP
• Immunogen: Synthetic peptide (125 VKAFLDRPSQPTQETKKN 142) of TxNIP protein.
• Purification Method: Protein A
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Polyclonal
• Target Species: Human, Non-human Primate

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% sodium azide
• Gene Accession No.: Q8BG60, Q9H3M7
• Gene Alias: EST01027, HHCPA78, THIF, VDUP1, thioredoxin binding protein 2, thioredoxin-binding protein 2, thioredoxin-interacting protein, upregulated by 1,25-dihydroxyvitamin D-3, vitamin D3 up-regulated protein 1
• Host Species: Rabbit
• Isotype: IgG
• Quantity: 100 μg
• Storage Requirements: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Primary or Secondary: Primary
• Gene ID (Entrez): 10628, 56338