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Invitrogen™ ZMIZ1 Polyclonal Antibody
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Catalog No. PIPA521133
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100 μg
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Catalog No. Quantity
PIPA521133 100 μg
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Catalog No. PIPA521133 Supplier Invitrogen™ Supplier No. PA521133
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Description

Rabbit Polyclonal Antibody

A suggested positive control is K562 cell lysate. PA5-21133 can be used with blocking peptide PEP-1247.

Retinoic acid plays a critical role in development, cellular growth, and differentiation and induces the expression of a variety of genes. RAI17 expression is induced by retinoic acid and is predominantly expressed in heart, brain and ovaries. Within brain, highest expression is in amygdala. The deduced 1,067-amino acid protein contains an MSX-interacting zinc finger (MIZ) domain, a nuclear localization signal sequence, and 2 proline-rich regions. A strong intrinsic transactivation domain is identified in the C-terminal proline-rich region. RAI17 expression is detected in various cancer cell lines. RAI17 colocalizes with endogenous androgen receptor (AR) in the nuclei of prostate epithelial cells from human tissue samples. In human prostate cancer cells, RAI17 increases the transcriptional activity of AR. Studies using sumoylation-deficient AR mutants suggest that the increase of AR activity by RAI17 is dependent upon receptor sumoylation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZMIZ1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene ZMIZ1
Gene Accession No. Q9ULJ6
Gene Alias BC065120; E330020C23; ENSMUSG00000072684; FLJ00092 protein; Gm10397; hZIMP10; I920194n01; KIAA1224; MIZ; PIAS-like protein Zimp10; Rai17; retinoic acid induced 17; retinoic acid-induced protein 17; RP11-519K18.1; TRAFIP10; Zimp10; Zinc finger MIZ domain-containing protein 1; zinc finger MIZ-type containing 1; zinc finger, MIZ-type containing 1; zinc finger-containing, Miz1, PIAS-like protein on chromosome 10; ZMIZ1
Gene Symbols ZMIZ1
Host Species Rabbit
Immunogen A 15 amino acid peptide near the amino terminus of human ZIMP10.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57178
Target Species Human
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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