Cayman Chemical ANTIBODY SKF 86002 5mg

Supplier:  Cayman Chemical 302025 MG

A dipeptide pan-caspase inhibitor inhibits caspase-1 (IC50 20 nM) caspase-3 (IC50 30 nM) and caspase-6 -7 -8 and -9 (IC50s 5-18 nM) selective for caspases over calpain I cathepsin B cathepsin D renin thrombin and Factor Xa (IC50s 10 M) inhibits anti-Fas antibody-induced caspase-3 processing and PARP cleavage in Jurkat cells at 0 05 M increases survival in a mouse model of anti-Fas antibody-induced liver failure at 0 25 mg/kg reduces infarct size in rat models of acute myocardial infarction-reperfusion or transient focal brain ischemia-reperfusion injury intravenously as a 20 mg/kg bolus dose followed by a 5 mg/kg per hour infusion

Catalog No. 50-298-8513