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Cayman Chemical ANTIBODY YCH1899 1mg
Supplier: Cayman Chemical 397371 MG
A PARP1 and PARP2 inhibitor (IC50s = 50s = 1-14.1 nM); inhibits the proliferation of Capan-1 cells (IC50 = 0.1 nM), as well as talazoparib- or olaparib-resistant Capan-1 cells (IC50s = 1.13 and 0.89 nM, respectively); inhibits the proliferation of BRCA1 mutant HCC1937 breast cancer cells (IC50 = 4.54 nM); reduces tumor growth in an olaparib-resistant MDA-MB-436 breast cancer mouse xenograft model at 12.5 and 25 mg/kg
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