AP1/JUN/P39 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Catalog No.	Quantity
50-173-3728	150 μL

Catalog No. 50-173-3728 Supplier Proteintech Group Inc Supplier No. 221141AP150UL

Description

Rabbit Polyclonal Antibody

Fos and Jun dimerize to form Activator Protein-1 (AP-1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13-acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the ′leucine-zipper′ motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP-1 dependent genes.

Specifications

• Antigen: AP1/JUN/P39
• Applications: Immunocytochemistry, Immunofluorescence, Western Blot
• Classification: Polyclonal
• Concentration: 0.35 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: JUN
• Gene Accession No.: P05412, P05627, P17325
• Gene Alias: Activator protein 1, AP 1, AP1, c Jun, JUN, jun oncogene, P39, Proto oncogene c Jun, Transcription factor AP 1
• Gene Symbols: JUN
• Host Species: Rabbit
• Immunogen: AP1,JUN,P39 Fusion Protein Ag17419
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 16476, 24516, 3725
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG