AP2M1 Mouse anti-Human, Mouse, Clone: OTI2G2, lyophilized, TrueMAB™

Catalog No.	Quantity
50-166-1811	100 μg

Catalog No. 50-166-1811 Supplier OriGene Supplier No. CF503017

Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

The heterotetrameric coat assembly protein complex, also known as the adaptor-related protein complex 2 (AP-2), belongs to the adaptor complexes medium subunits family. The mu 1 subunit of the AP-2 complex (AP2M1) is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. AP2M1 has also been shown to associate with the HIV-1 protein Nef, suggesting that Nef may use AP-2 complex to enhance the rate of endocytosis of both CD4 and class I MHC. AP2M1 may also play an important role in regulating the intracellular trafficking and function of cytotoxic T-lymphocyte associated (CTLA)-4 protein. At least two isoforms of AP2M1 are known to exist.

Specifications

• Antigen: AP2M1
• Applications: Flow Cytometry, Western Blot
• Classification: Monoclonal
• Clone: OTI2G2
• Conjugate: Unconjugated
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene: AP2M1
• Gene Accession No.: P84091, Q96CW1
• Gene Alias: AP50, CLAPM1, mu2
• Gene Symbols: Ap2m1
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 97-383 of human AP2M1 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1173, 11773
• Target Species: Human, Mouse
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG2a