AP2M1 Mouse anti-Canine, Human, Rat, Clone: OTI 2F11, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525572

Catalog No. PIMA525572

Description

The heterotetrameric coat assembly protein complex, also known as the adaptor-related protein complex 2 (AP-2), belongs to the adaptor complexes medium subunits family. The mu 1 subunit of the AP-2 complex (AP2M1) is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. AP2M1 has also been shown to associate with the HIV-1 protein Nef, suggesting that Nef may use AP-2 complex to enhance the rate of endocytosis of both CD4 and class I MHC. AP2M1 may also play an important role in regulating the intracellular trafficking and function of cytotoxic T-lymphocyte associated (CTLA)-4 protein. At least two isoforms of AP2M1 are known to exist.

Specifications

• Antigen: AP2M1
• Classification: Monoclonal
• Concentration: 0.98 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q96CW1, P84092
• Gene Alias: AP50, CLAPM1, mu2; AP-2 complex subunit mu; AP-2 mu 2 chain; AP-2 mu chain; HA2 50 kDA subunit; adapter-related protein complex 2 mu subunit; adaptin-mu2; adaptor protein complex AP-2 subunit mu; clathrin adaptor complex AP2, mu subunit; clathrin assembly protein complex 2 medium chain; clathrin coat adaptor protein AP50; clathrin coat assembly protein AP50; clathrin coat-associated protein AP50; clathrin-associated/assembly/adaptor protein, medium 1; plasma membrane adaptor AP-2 50 kDa protein;
• Host Species: Mouse
• Isotype: IgG1
• Quantity: 100 μL
• Storage Requirements: -20° C, Avoid Freeze/Thaw Cycles
• Primary or Secondary: Primary
• Gene ID (Entrez): 116563, 1173, 607139

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI 2F11
• Conjugate: Unconjugated
• Gene: AP2M1
• Format: Liquid
• Gene Symbols: AP2M1
• Immunogen: Human recombit protein fragment corresponding to amino acids 97-383 of AP2M1 produced in E.coli
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Monoclonal
• Target Species: Canine, Human, Rat