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ABclonal Technology APC/Cy7 anti-h/Mk CD19
Supplier: ABclonal Technology A27650100T
This gene encodes a cell surface protein in the immunoglobulin superfamily expressed exclusively on B cell lymphocytes It serves as a marker for pre-B cells with expression decreasing as B cells differentiate into antibody-secreting plasma cells The protein contains two N-terminal Ig-like domains a non-Ig-like domain a transmembrane region and a large cytoplasmic domain It forms a complex with CD21 and CD81 lowering the threshold for antigen-triggered B cell activation which activates the PI3K signaling pathway and calcium release This protein is targeted by CAR T-cells for treating lymphoblastic leukemia Mutations are linked to common variable immunodeficiency 3 (CVID3) causing impaired B-cell differentiation hypogammaglobulinemia inability to respond to antigens and recurrent infections Alternative splicing produces multiple transcript variants encoding distinct isoforms
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