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Invitrogen™ APEX2 Polyclonal Antibody
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Catalog No. 01675646
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01-675-646 200 μL
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Catalog No. 01-675-646 Supplier Invitrogen™ Supplier No. PA141306
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Description

Rabbit Polyclonal Antibody

Suggested positive control: Hela whole cell extract. Predicted cross-reactivity based on sequence identity (not validated): Mouse, Rat. Immunogen sequence: EELRALDSEG RALLTQHKI & GQAKTSEAKD EKELRTSF.

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER).
TRUSTED_SUSTAINABILITY

Specifications

Antigen APEX2
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA and 0.02% sodium azide
Gene APEX2
Gene Accession No. Q9UBZ4
Gene Alias AP endonuclease 2; AP endonuclease XTH2; Ape2; APEX nuclease (apurinic/apyrimidinic endonuclease) 2; APEX nuclease 2; APEX nuclease-like 2; APEX2; APEXL2; apurinic/apyrimidinic endodeoxyribonuclease 2; apurinic/apyrimidinic endonuclease 2; apurinic/apyrimidinic endonuclease-like 2; Apurinic-apyrimidinic endonuclease 2; C430040P13Rik; DNA-(apurinic or apyrimidinic site) lyase 2; RP5-884M20.3; XTH2; ZGRF2; zinc finger, GRF-type containing 2
Gene Symbols APEX2
Host Species Rabbit
Immunogen Peptides of human APEX2 (aa 122-140 and 438-455).
Purification Method Protein G
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27301
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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