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API-1, Tocris Bioscience™

Catalog No. 389710
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Catalog No. Quantity
38-971-0 10 mg
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Catalog No. 38-971-0 Supplier R&D Systems Supplier No. 3897/10
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Description

Selective Akt/PKB inhibitor. Antitumor

Akt/protein kinase B (PKB) inhibitor. Binds the pleckstrin homology domain of Akt and blocks Akt membrane translocation. Inhibits EGF-induced kinase activity of Akt1, Akt2 and Akt3. Induces cell growth arrest and apoptosis in human cancer cells expressing constitutively active Akt. Displays antitumor activity in vitro and in vivo.

Chemical Identifiers

CAS 36707-00-3
Molecular Formula C13H15N5O6
Molecular Weight (g/mol) 337.292
InChI Key SPBWHPXCWJLQRU-FITJORAGSA-N
Synonym api-1, 4-amino-8-3,4-dihydroxy-5-hydroxymethyl oxolan-2-yl-5-oxo, 4-amino-5,8-dihydro-5-oxo-8-?-d-ribofuranosyl-pyrido 2,3-d pyrimidine-6-carboxamide, 4-amino-5,8-dihydro-5-oxo-8-beta-d-ribofuranosyl-pyrido 2,3-d pyrimidine-6-carboxamide, 4-amino-8-2r,3r,4s,5r-3,4-dihydroxy-5-hydroxymethyl oxolan-2-yl-5-oxopyrido 2,3-d pyrimidine-6-carboxamide
PubChem CID 24773090
IUPAC Name 4-amino-8-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide
SMILES C1=C(C(=O)C2=C(N1C3C(C(C(O3)CO)O)O)N=CN=C2N)C(=O)N

Specifications

Quantity 10 mg
Formula Weight 337.29
Percent Purity >96%
Chemical Name or Material API-1

Safety and Handling

Recommended Storage Store at Room Temperature
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