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AdipoGen anti-APRIL (human), mAb (blocking) (Mahya-1) (preservative free) (500 µg)
Supplier: AdipoGen AG20B0078PFC500
Monoclonal Antibody. Recognizes human APRIL. Does not recognize mouse APRIL or mouse and human BAFF. Applications: ELISA, FUNC (Blocking), IP. Isotype: Mouse IgG1 kappa. Clone: Mahya-1. Liquid. In PBS. The B cell-stimulating molecules, BAFF (B cell activating factor) and APRIL (a proliferation-inducing ligand), are critical factors in the maintenance of the B cell pool and humoral immunity. APRIL maintains B cell homeostasis by acting at a later stage, modulating the function and survival of antigen-experienced B cells. APRIL (a proliferation-inducing ligand) is implicated in several human autoimmune diseases with autoreactive B cell involvement, including systemic lupus erythematosus (SLE), Sjögren’s syndrome (SS), IgA nephropathy (IgAN) and rheumatoid arthritis (RA). APRIL might also function in enhancing proliferation of some tumor cells, especially B-cell malignancies.
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