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Invitrogen™ Aquaporin 2 Polyclonal Antibody
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Catalog No. PIPA538004
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100 μg
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Catalog No. Quantity
PIPA538004 100 μg
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Catalog No. PIPA538004 Supplier Invitrogen™ Supplier No. PA538004
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Description

Rabbit Polyclonal Antibody

A recommended positive control is A431 cell lysate. This antibody is not expected to cross-react with other members of the aquaporin protein family.

Aquaporin 2 (AQP2) is a hormonally regulated water channel located in the renal collecting duct. Mutations in the AQP2 gene cause hereditary nephrogenic diabetes insipidus in humans. A vasopressin induced cAMP increase results in the phosphorylation of AQP2 at serine-256 and its translocation from the intracellular vesicles to the apical membrane of principal cells. Recently, serine-261 has been identified as a novel phosphorylation site on AQP2 and levels of phosphorylated S261 have been shown to decrease with vasopressin treatment suggesting its involvement in vasopressin-dependent AQP2 trafficking.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Aquaporin 2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Aqp2
Gene Accession No. P34080, P41181, P56402
Gene Alias ADH water channel; AQP 2; AQP CD; Aqp2; AQP-2; AQPCD; AQP-CD; aquaporin 2; aquaporin 2 (collecting duct); Aquaporin CD; Aquaporin2; aquaporin-2; Aquaporin-CD; Aquaporine 2; collecting duct water channel protein; cph; jpk; MGC34501; Water channel protein for renal collecting duct; water-channel aquaporin 2; WCH CD; WCHCD; WCH-CD
Gene Symbols Aqp2
Host Species Rabbit
Immunogen 19 amino acid peptide near the carboxy terminus of human AQP2.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11827, 25386, 359
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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