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Arctigenin, Tocris Bioscience™

Catalog No. 177750
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Quantity:
10 mg
50 mg
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Description

Potent MEK1 inhibitor. Also inhibits IκBα phosphorylation

Antioxidant, anti-inflammatory, antiproliferative and antiviral agent. Inhibits LPS-induced iNOS expression via inhibition of IκBα phosphorylation and p65 nuclear translocation (IC50 = 10 nM). Inhibits HIV-1 replication in vitro. Also potently inhibits MKK1 (MEK1) (IC50 = 0.5 nM) and provides neuroprotection by binding to kainate receptors.

Chemical Identifiers

CAS 7770-78-7
Molecular Formula C21H24O6
Molecular Weight (g/mol) 372.417
InChI Key NQWVSMVXKMHKTF-JKSUJKDBSA-N
Synonym arctigenin, --arctigenin, unii-u76mr9vs6m, u76mr9vs6m, 2 3h-furanone, 4-3,4-dimethoxyphenyl methyl dihydro-3-4-hydroxy-3-methoxyphenyl methyl-, 3r-trans, 2 3h-furanone, 4-3,4-dimethoxyphenyl methyl dihydro-3-4-hydroxy-3-methoxyphenyl methyl-, 3r,4r, 3r,4r-4-3,4-dimethoxyphenyl methyl-3-4-hydroxy-3-methoxyphenyl methyl oxolan-2-one, 3r,4r-4-3,4-dimethoxyphenyl methyl dihydro-3-4-hydroxy-3-methoxyphenyl methyl-2 3h-furanone, +/--arctigenin, arctigenin, +/-
PubChem CID 64981
ChEBI CHEBI:79
IUPAC Name (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one
SMILES COC1=C(C=C(C=C1)CC2COC(=O)C2CC3=CC(=C(C=C3)O)OC)OC

Specifications

Quantity 50 mg
Formula Weight 372.42
Percent Purity >98%
Chemical Name or Material Arctigenin

Safety and Handling

Recommended Storage Desiccate at -20°C
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