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  6. Invitrogen™ Arginase 1 Monoclonal Antibody (A1exF5), Brilliant Violet™ 650, eBioscience™, Invitrogen™ 

Invitrogen™ Arginase 1 Monoclonal Antibody (A1exF5), Brilliant Violet™ 650, eBioscience™, Invitrogen™
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Catalog No. 416369782
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Catalog No. Quantity
41-636-9782 100 μg
41-636-9780 25 μg
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Catalog No. 41-636-9782 Supplier Invitrogen™ Supplier No. 416369782
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Description

Rat Monoclonal Antibody

Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, which is the final step in the urea cycle. The resulting polyamines are important for cell proliferation and removal of toxins that arise from protein degradation. By degrading arginine, Arginase 1 deprives NO synthase of its substrate and down-regulates nitric oxide production. In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid derived suppressor cells (MDSC) and neural stem cells. In human, expression in blood neutrophils but not in CCR3+ granulocytes has been reported. In mice, expression of Arginase 1 is one of the hallmarks of alternatively activated macrophages (M2a). Arginase-1 may be expressed in the myeloid cells infiltrating tumors, and is typically found in the majority of hepatocellular carcinomas. Defects in Arginase 1 are the cause of argininemia, an autosomal recessive disorder characterized by hyperammonemia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Arginase 1
Applications Flow Cytometry
Classification Monoclonal
Clone A1exF5
Concentration 0.2 mg/mL
Conjugate Brilliant Violet 650
Formulation PBS with BSA and 0.09% sodium azide; pH 7.2
Gene ARG1
Gene Accession No. P05089, Q61176
Gene Alias AI; A-I; AI type I arginase; AI256583; Arg1; Arg-1; Arginase; arginase 1; arginase 1 liver; arginase 1, liver; arginase I; arginase, liver; Arginase1; arginase-1; HGNC:663; Liver Arginase; Liver-type arginase; PGIF; similar to arginase, type I; Type 1 Arginase; type I arginase
Gene Symbols ARG1
Host Species Rat
Immunogen E.coli-derived recombinant mouse Arginase 1.
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11846, 383
Target Species Human, Mouse
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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