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  6. Invitrogen™ Arginase 1 Recombinant Rabbit Monoclonal Antibody (BLR161J)

Invitrogen™ Arginase 1 Recombinant Rabbit Monoclonal Antibody (BLR161J)
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Catalog No. p-200121705
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100 μL
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PIMA544507 100 μL
PIMA544508 10 μL
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Catalog No. PIMA544507 Supplier Invitrogen™ Supplier No. MA544507
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Description

Rabbit Recombinant Monoclonal Antibody

Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE tissue sections.

Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, which is the final step in the urea cycle. The resulting polyamines are important for cell proliferation and removal of toxins that arise from protein degradation. By degrading arginine, Arginase 1 deprives NO synthase of its substrate and down-regulates nitric oxide production. In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid derived suppressor cells (MDSC) and neural stem cells. In human, expression in blood neutrophils but not in CCR3+ granulocytes has been reported. In mice, expression of Arginase 1 is one of the hallmarks of alternatively activated macrophages (M2a). Arginase-1 may be expressed in the myeloid cells infiltrating tumors, and is typically found in the majority of hepatocellular carcinomas. Defects in Arginase 1 are the cause of argininemia, an autosomal recessive disorder characterized by hyperammonemia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Arginase 1
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Recombinant Monoclonal
Clone BLR161J
Concentration 100 μg/mL
Conjugate Unconjugated
Formulation BBS with 0.1% BSA and 0.09% sodium azide; pH 8.2
Gene ARG1
Gene Accession No. Q61176
Gene Alias AI; A-I; AI type I arginase; AI256583; Arg1; Arg-1; Arginase; arginase 1; arginase 1 liver; arginase 1, liver; arginase I; arginase, liver; Arginase1; arginase-1; HGNC:663; Liver Arginase; Liver-type arginase; PGIF; similar to arginase, type I; Type 1 Arginase; type I arginase
Gene Symbols ARG1
Host Species Rabbit
Immunogen Recombinant protein representing full length Arginase 1.
Purification Method Purified
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11846
Target Species Mouse
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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