ARHGAP24 Rabbit anti-Canine, Human, Mouse, Rat, Zebrafish, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-173-2250	Proteintech Group Inc 188341AP150UL	150 μL

Description

The antibody may recognize all the isoforms of ARHGAP24 except isoform 5.

Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.

Specifications

• Antigen: ARHGAP24
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Canine, Human, Mouse, Rat, Zebrafish
• Gene Accession No.: Q5U2Z7, Q8C4V1, Q8N264
• Gene ID (Entrez): 100005116, 231532, 305156, 478463, 83478
• Immunogen: Peptide
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: ARHGAP24

• Concentration: 0.31 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: ARHGAP24, Filamin A associated RhoGAP, FILGAP, p73, p73RhoGAP, RC GAP72, RCGAP72, Rho type GTPase activating protein 24, RhoGAP of 73 kDa, Sarcoma antigen NY SAR 88
• Gene Symbols: ARHGAP24
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody