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Invitrogen™ ARHGEF3 Polyclonal Antibody
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Catalog No. PA550332
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100 μL
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PA550332 100 μL
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Catalog No. PA550332 Supplier Invitrogen™ Supplier No. PA550332
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Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total ARHGEF3 protein.

Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ARHGEF3
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.9 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene ARHGEF3
Gene Accession No. Q9NR81
Gene Alias 1200004I24Rik; 59.8 kDA protein; 9830169H03Rik; ARHG3; ARHGEF3; C76747; DKFZP434F2429; Exchange factor found in platelets and leukemic and neuronal tissues; exchange factor found in platelets and leukemic and neuronal tissues, XPLN; GEF3; MGC118905; Rho guanine nucleotide exchange factor (GEF) 3; Rho guanine nucleotide exchange factor 3; RhoGEF protein; STA3; Xpln
Gene Symbols ARHGEF3
Host Species Rabbit
Immunogen Fusion protein corresponding to residues near the N terminal of human Rho guanine nucleotide exchange factor (GEF) 3.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 50650
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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