Invitrogen™ ARID1A Polyclonal Antibody

Catalog No.	Quantity
PIPA585568	100 μL

Catalog No. PIPA585568 Supplier Invitrogen™ Supplier No. PA585568

Description

Rabbit Polyclonal Antibody

Keep as concentrated solution. Predicted reactivity: Mouse (81%), Bovine (84%). Positive Control: 293T, A431, HeLa, A549, HepG2, HepG2 nuclear extract. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: ARID1A
• Applications: ChIP Assay, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.53 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene: ARID1A
• Gene Accession No.: A2BH40, O14497
• Gene Alias: 1110030E03Rik; ARID domain-containing protein 1A; ARID1A; AT rich interactive domain 1A (Swi1 like); AT rich interactive domain 1A (SWI-like); AT-rich interaction domain 1A; AT-rich interactive domain-containing protein 1A; B120; BAF250; Baf250a; BM029; brain protein 120; BRG1-associated factor 250; BRG1-associated factor 250a; C1orf4; chromatin remodeling factor p250; CSS2; ELD; h BM029; hELD; hOSA1; MRD14; Osa homolog 1; Osa1; OSA1 nuclear protein; P270; Smarcf1; SWI/SNF complex protein p270; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily f, member 1; SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1; Swi1 like; SWI-like protein; SWI-SNF complex protein p270
• Gene Symbols: ARID1A
• Host Species: Rabbit
• Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human ARID1A. The exact sequence is proprietary.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 8289, 93760
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov