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Apexbio Technology LLC ARRY-380 937265-83-3 5mg
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Supplier:  Apexbio Technology LLC A83665

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ARRY-380 (CAS 937265-83-3) is an orally bioavailable reversible ATP-competitive inhibitor of the HER2 (ErbB2) tyrosine kinase Demonstrating high selectivity approximately 500-fold greater for HER2 over EGFR ARRY-380 inhibits HER2 activity at nanomolar concentrations in vitro and is active against truncated HER2 isoforms such as p95-HER2 In preclinical models of ErbB2-driven intracranial tumors ARRY-380 improved survival and exhibited greater efficacy compared to other ErbB2-targeted agents Early clinical studies in patients with HER2-positive metastatic breast cancer reported tolerability without dose-limiting toxicity and evidence of antitumor activity ARRY-380 is a valuable tool for investigating HER2 signaling and evaluating targeted therapies in HER2-driven malignancies

Catalog No. 50-000-93832


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