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Artemis Polyclonal Antibody, Bethyl Laboratories

Catalog No. p-7144318
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50-157-2046 10 μL
50-157-2045 100 μL
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Catalog No. 50-157-2046 Supplier Bethyl Laboratories, Inc Supplier No. IHC00408T
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Chimpanzee, Bolivian red howler monkey, Northern white-cheeked gibbon and Francois's l

Distinct DNA repair pathways minimize the consequences of mutagenic events. Reactive oxygen species (ROS) are highly reactive atoms with an unpaired electron that are conducive to double-strand DNA breaking events. Artemis, named after the Greek goddess for the protection of children, is one of the major proteins contributing to the preservation of double-strand breaks in DNA by cutting away the damaged parts of the DNA, which allows the strands to rejoin. Artemis is a single-strand-specific 5′ to 3′ exonuclease that forms a complex with the 469 kDa DNA-dependent protein kinase (DNA-PKcs). DNA-PKcs phosphorylates Artemis, and Artemis acquires endonucleolytic activity on 5′ and 3′ overhangs and hairpins. These activities are essential for V(D)J recombination and for the 5′ and 3′ overhang processing in nonhomologous DNA end joining.

Specifications

Antigen Artemis
Applications Immunohistochemistry
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene DCLRE1C
Gene Accession No. Q96SD1
Gene Alias ASCID, DCLRE1C DNA cross link repair 1C, DCLRE1C protein, DCLREC1C, DNA cross link repair 1C, FLJ11360, RS SCID, SCIDA, Severe combined immunodeficien
Gene Symbols DCLRE1C
Host Species Rabbit
Immunogen Between 650 and C-term
Purification Method Antigen affinity chromatography
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 64421
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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