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Apexbio Technology LLC AS 1949490 1203680-76-5 50mg
Supplier: Apexbio Technology LLC B748350
AS 1949490 (CAS 1203680-76-5) is a selective inhibitor of SH2 domain-containing inositol 5-phosphatase 2 (SHIP2) exhibiting IC50 values of 0 34 M and 0 62 M for mouse and human SHIP2 respectively SHIP2 negatively regulates insulin signaling via its phosphatase activity In cellular studies AS 1949490 dose-dependently enhanced insulin-induced phosphorylation of Akt in L6 myotubes without altering total Akt levels or serum-induced phosphorylation The compound also increased insulin-stimulated glucose consumption in cultured cells In db/db diabetic mice oral administration of AS 1949490 significantly reduced blood glucose concentrations without affecting insulin levels food intake or body weight This molecule is utilized for investigating SHIP2 function and exploring therapeutic strategies for insulin resistance and type 2 diabetes
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