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Invitrogen™ ASAH3 Polyclonal Antibody
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Catalog No. PIPA5103592
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PIPA5103592 100 μL
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Catalog No. PIPA5103592 Supplier Invitrogen™ Supplier No. PA5103592
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total ASAH3.

Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ASAH3
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene ACER1
Gene Accession No. Q8R4X1, Q8TDN7
Gene Alias 2310024P18Rik; 3.5.1.23; ACER1; Acylsphingosine deacylase 3; AI662009; alkaline CDase 1; alkaline ceramidase 1; AlkCDase 1; ALKCDase1; ASAH3; Cer1; CTB-180A7.3; maCER1; N-acylsphingosine amidohydrolase (alkaline ceramidase) 3; N-acylsphingosine amidohydrolase 3
Gene Symbols ACER1
Host Species Rabbit
Immunogen A synthesized peptide derived from human ACER1(Accession Q8TDN7), corresponding to amino acid residues P139-S189.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 125981, 171168, 301118
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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