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Apexbio Technology LLC Ascomycin(FK 520) 104987-12-4 50mg
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Supplier:  Apexbio Technology LLC A319150

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Ascomycin FK 520 (CAS 104987-12-4) is a small-molecule immunosuppressant targeting calcineurin phosphatase via binding to immunophilin FKBP12 It is designed to inhibit calcineurin activity thereby suppressing NFAT-mediated T-cell activation and proliferation Ascomycin FK 520 exerts its biological activity primarily by forming a complex with FKBP12 that inhibits calcineurin phosphatase In in vitro assays Ascomycin FK 520 demonstrates dose-dependent inhibition of lymphocyte responsiveness with an IC50 in the submicromolar range and no cytotoxicity observed below 3 2 M In animal models administration at doses 3 2 mg/kg prolongs skin transplant survival in rats Based on these pharmacological properties Ascomycin FK 520 holds research potential in studies of calcineurin-mediated immune responses and the development of T-cell modulation strategies

Catalog No. 50-000-95198


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