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Invitrogen™ ASK Recombinant Rabbit Monoclonal Antibody (0S8I5)
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Catalog No. PIMA542736
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PIMA542736 100 μL
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Catalog No. PIMA542736 Supplier Invitrogen™ Supplier No. MA542736
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Description

Rabbit Recombinant Monoclonal Antibody

Positive test controls include: PC-3, Jurkat. Immunogen sequence: MNSGAMRIHS KGHFQGGIQV KNEKNRPSLK SLKTDNRPEK SKCKPLWGKV FYLDLPSVTI SEKLQKDIKD LGGRVEEFLS KDISYLISNK KEAKFAQTLG.

Activator of S phase kinase (ASK, DBF4) is a novel regulatory subunit of the human Cdc7 kinase complex that plays a pivotal role in G1/S cell cycle transition in mammalian cells. The increase in Cdc7 kinase activity at the G1/S boundary is at least partly accounted for by the elevated expression of ASK in late G1. ASK interacts with replication origins in vivo, suggesting that Cdc7 may trigger S phase by directly activating the replication initiation complexes assembled at the origins. Human ASK protein levels are regulated during the cell cycle with a pattern that matches that of human Cdc7 protein kinase activity. Human Cdc7-ASK kinase is directly involved in regulating the initiation of DNA replication by targeting MCM2 protein in mammalian cells. Nuclear localization and chromatin binding of endogenous huCdc7 and GFP-ASK is presumably imported into nuclei through its two nuclear localization signals at telophase, it may require additional signals for chromatin binding, the level of which increases at late G1 ohase. A functional link may exist between menin, a tumor suppressor protein mutated in multiple endocrine neoplasia type I (MEN1), and ASK in the regulation of cell proliferation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ASK
Applications ELISA, Western Blot
Classification Recombinant Monoclonal
Clone 0S8I5
Concentration 0.35 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene DBF4
Gene Accession No. Q9UBU7
Gene Alias AA545217; Activator of S phase kinase; ASK; CHIF; chiffon homolog A; Dbf4; DBF4 homolog; DBF4 homolog (S. cerevisiae); DBF4 zinc finger; DBF4 zinc finger A; DBF4A; DBF4-type zinc finger-containing protein 1; MuDBF4; Protein DBF4 homolog A; RGD1305854; ZDBF1; zinc finger, DBF-type containing 1
Gene Symbols DBF4
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DBF4 (Q9UBU7).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10926
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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