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Apexbio Technology LLC AGI-6780 1432660-47-3 100mg
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Supplier:  Apexbio Technology LLC A3146100

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AGI-6780 (CAS 1432660-47-3) is a potent and selective inhibitor of the oncogenic IDH2/R140Q mutant enzyme exhibiting an IC50 of 23 nM In cellular assays AGI-6780 effectively reduces intracellular 2-hydroxyglutarate (2HG) levels in TF1/R140Q human glioblastoma cells The compound also reverses the differentiation block mediated by IDH2/R140Q in TF1 cells in the presence of erythropoietin restoring erythroid marker expression such as KLF1 and Hemoglobin G1/2 AGI-6780 serves as a valuable tool for studying mutant IDH2-driven metabolic alterations and cellular differentiation processes in cancer research

Catalog No. 50-000-95256


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