Invitrogen™ Ataxin 3 Monoclonal Antibody (2SCA-1H9)

Catalog No.	Quantity
PIMA3082	50 μL

Catalog No. PIMA3082 Supplier Invitrogen™ Supplier No. MA3082

Description

Mouse Monoclonal Antibody

MA3-082 detects Ataxin 3 from human, mouse and rat samples. MA3-082 has been successfully used in Western blot, immunofluorescence, and ELISA applications. MA3-082 has been successfully used in Western blot, immunofluorescence, and ELISA applications. The MA3-082 immunogen is the human ataxin-3 fragment from aa 112 - aa L249 as a fusion protein.

Machado-Joseph disease is an autosomal dominant neurologic disorder, and is now known to be the same as previously described spinocerebellar ataxia-3. MJD protein (Ataxin-3) contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. This protein interacts with key regulators (CBP, p300 and PCAF) of transcription and represses transcription, and also acts as a histone-binding protein that regulates transcription. MJD is a deubiquitinating enzyme.

Specifications

• Antigen: Ataxin 3
• Applications: Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: 2SCA-1H9
• Concentration: Conc. Not Determined
• Conjugate: Unconjugated
• Formulation: ascites with 0.05% sodium azide
• Gene: ATXN3
• Gene Accession No.: O35815, P54252, Q9CVD2
• Gene Alias: 2210008M02Rik; AI463012; AI647473; AT3; ataxin 3; ataxin 3 variant an; ataxin 3 variant ao; ataxin 3 variant at; ataxin 3 variant e; ataxin 3 variant h; ataxin 3 variant m; ataxin 3 variant r; ataxin 3 variant ref; ataxin 3 variant y; ataxin3; ataxin-3; ATX3; ATXN3; JOS; josephin; Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3); Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3) homolog; Machado-Joseph disease protein 1; Machado-Joseph disease protein 1 homolog; MJD; MJD1; olivopontocerebellar ataxia 3; Rsca3; Sca3; spin; Spinocerebellar ataxia type 3 protein
• Gene Symbols: ATXN3
• Host Species: Mouse
• Immunogen: Human Ataxin-3 fragment from aa F112-aa L249.
• Quantity: 50 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 110616, 4287, 60331
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1 κ

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov