Invitrogen™ Ataxin 7 Polyclonal Antibody

Catalog No.	Quantity
PA1749	100 μg

Catalog No. PA1749 Supplier Invitrogen™ Supplier No. PA1749

Description

Rabbit Polyclonal Antibody

PA1-749 detects ataxin 7 protein from transfected cell lysate. PA1-749 has successfully been used in immunohistochemistry and Western blot procedures. By Western blot, this antibody detects an ~96 kDa protein representing human ataxin 7 in transfected COS-1 cells. The PA1-749 immunizing peptide corresponds to amino acid residues 1-17 from human ataxin 7. This sequence is completely conserved in mouse ataxin 7. This peptide (Cat. # PEP-217) is available for use in neutralization and control experiments.

Spinocerebellar ataxia type 7 (SCA7) belongs to a class of hereditary neurodegenrative diseases characterized by abnormally expanded polyglutamine (CAG) repeats at the N-terminus. This autosomal dominant cerebellar ataxia primarily affects the cerebellum, retina, and brain stem and causes dementia, macular degeneration and other neurodegenerative characteristics. SCA7 gene encodes the ubiquitous 892 residue protein ataxin-7. This protein is typically located in the cytoplasm and on the nuclear membrane of normal brain neurons. In cells where there is a mutation of the SCA7 gene, ataxin 7 accumulates in intranuclear inclusions and can result in cell death.

Specifications

• Antigen: Ataxin 7
• Applications: Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide
• Gene: ATXN7
• Gene Accession No.: O15265
• Gene Alias: A430107N12Rik; ADCAII; AI627028; Ataxin 7; Ataxin7; Ataxin-7; ATXN7; Atxn7-PA; Atxn7-PB; Atxn7-PC; Atxn7-PD; CG9866; CG9866-PA; CG9866-PB; CG9866-PC; CG9866-PD; Dmel\CG9866; Dmel_CG9866; LD40170p; OPCA3; RGD1562692; SCA7; spinocerebellar ataxia 7 homolog; spinocerebellar ataxia type 7 protein; Spinocerebellar ataxia type 7 protein homolog
• Gene Symbols: ATXN7
• Host Species: Rabbit
• Immunogen: Synthetic Peptide: M(1) S E R A A D D V R G E P R R A A(17) C.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 33423, 6314
• Target Species: Human, Drosophila
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG