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ATF2 Rabbit anti-Human, Polyclonal, Bethyl Laboratories
Description
The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Mouse
The transcription factor ATF-2 (also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins. ATF-2 interacts with a variety of viral oncoproteins and cellular tumor suppressors and is a target of the SAPK/JNK and p38 MAP kinase signaling pathways. Various forms of cellular stress, including genotoxic agents, inflammatory cytokines and UV irradiation, stimulate the transcriptional activity of ATF-2. Cellular stress activates ATF-2 by phosphorylation of Thr69 and Thr71. Both SAPK and p38 MAPK have been shown to phosphorylate ATF-2 at these sites in vitro and in cells transfected with ATF-2.
Specifications
Specifications
| Antigen | ATF2 |
| Applications | Immunoprecipitation |
| Classification | Polyclonal |
| Concentration | 1 mg/ml |
| Conjugate | Unconjugated |
| Formulation | phosphate, tris citrate with 0.09% sodium azide; pH 7-8 |
| Gene | ATF2 |
| Gene Accession No. | P15336 |
| Gene Alias | Activating Transcription Factor, CRE-BP1 |
| Gene Symbols | ATF2 |
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Product Title
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