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Invitrogen™ ATF4 Monoclonal Antibody ([N360A/24), PE
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Catalog No. PIMA545650
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100 μg
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PIMA545650 100 μg
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Catalog No. PIMA545650 Supplier Invitrogen™ Supplier No. MA545650
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Description

Mouse Monoclonal Antibody

86% identical to rat, and 85% identical to mouse. <50% identity with ATF5. 1 μg/mL of MA5-45650 was sufficient for detection of ATF4 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 60kDa. Does not cross-react with ATF5. This antibody was formerly sold as clone S360A-24.

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ATF4
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone [N360A/24
Concentration 1 mg/mL
Conjugate PE
Formulation 2.48mM MES, 95.64mM phosphate with 0.5M EDTA and no preservative; pH 7.4
Gene Atf4
Gene Accession No. P18848, Q9ES19
Gene Alias Activating transcription factor 4; activating transcription factor 4 (tax-responsive enhancer element B67); activating transcription factor 4a; activating transcription factor 4b1 (tax-responsive enhancer element B67); activating transcription factor ATF-4; ATF 4; atf4; Atf-4; atf4 {ECO:0000312; ATF4 protein; atf4a; atf4b1; C/ATF; C/EBP-related ATF; cAMP response element-binding protein 2; cAMP-dependent transcription factor ATF-4; cAMP-responsive element-binding protein 2; CREB 2; CREB2; CREB-2; Cyclic AMP-dependent transcription factor ATF-4; cyclic AMP-responsive element-binding protein 2; DNA-binding protein TAXREB67; hypothetical protein LOC509107; OTTHUMP00000199130; rATF-4; RGD:621863}; tax-re; TaxREB67; TaxREB67 homolog; tax-responsive enhancer element B67; tax-responsive enhancer element-binding protein 67; Tax-responsive enhancer element-binding protein 67 homolog; TXREB; wu:fj01c08; wu:fk30b04; zgc:85951
Gene Symbols Atf4
Host Species Mouse
Immunogen Fusion protein amino acids 25-327 of human ATF4.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 468, 79255
Target Species Human, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2a
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