ATG101 Rabbit anti-Human, Polyclonal, Proteintech

Catalog No.	Quantity
50-173-5378	150 μL

Catalog No. 50-173-5378 Supplier Proteintech Group Inc Supplier No. 265621AP150UL

Description

Rabbit Polyclonal Antibody

ATG101 is involved in autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1. ATG101 is a recently discovered protein that stabilizes ATG13, another autophagy protein that forms a complex with the mammalian homologs of ATG1, ULK1 and ULK2, and with FIP200. This complex is a target of TOR phosphorylation under normal conditions inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1 and ULK2, which then leads to autophagy. ATG101 also interacts with ULK1 and is essential for autophagy.

Specifications

• Antigen: ATG101
• Applications: Immunoprecipitation
• Classification: Polyclonal
• Concentration: 0.17 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene: ATG101
• Gene Accession No.: Q9BSB4
• Gene Alias: ATG101, Autophagy related protein 101, C12orf44
• Gene Symbols: ATG101
• Host Species: Rabbit
• Immunogen: ATG101 Fusion Protein Ag22932
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 60673
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG