Invitrogen™ ATG13 Monoclonal Antibody (3E4C8)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA531637

Catalog No. PIMA531637

Description

MA5-31637 has been tested in indirect ELISA.

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1. ATG13 forms a complex with ULK1 and ULK2, the mammalian homologs of ATG1, and with FIP200. This complex is a target of TOR phosphorylation under normal conditions; inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1 and ULK2, which then leads to autophagy. Knockdown of ATG13 inhibits autophagosome formation.

Specifications

• Antigen: ATG13
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% sodium azide
• Gene Accession No.: O75143
• Gene Symbols: ATG13
• Immunogen: Purified recombinant fragment of human ATG13 (AA: 339-550) expressed in E. coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Flow Cytometry, Western Blot, Immunocytochemistry
• Clone: 3E4C8
• Conjugate: Unconjugated
• Gene: ATG13
• Gene Alias: 1110053A20Rik; Atg13; ATG13 autophagy related 13 homolog; autophagy related 13; autophagy-related protein 13; D2Ertd391e; FLJ20698; Harbi1; Harbi1l; harbinger transposase derived 1; KIAA0652; OTTHUMP00000233321; OTTHUMP00000233322; OTTHUMP00000233323; OTTHUMP00000233324; OTTHUMP00000233325; OTTHUMP00000233326; PARATARG8; RGD1310685
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 9776
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid