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Invitrogen™ ATG13 Monoclonal Antibody (3E4C8)
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Catalog No. PIMA531637
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100 μL
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Catalog No. Quantity
PIMA531637 100 μL
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Catalog No. PIMA531637 Supplier Invitrogen™ Supplier No. MA531637
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Description

Mouse Monoclonal Antibody

MA5-31637 has been tested in indirect ELISA.

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1. ATG13 forms a complex with ULK1 and ULK2, the mammalian homologs of ATG1, and with FIP200. This complex is a target of TOR phosphorylation under normal conditions; inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1 and ULK2, which then leads to autophagy. Knockdown of ATG13 inhibits autophagosome formation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ATG13
Applications ELISA, Flow Cytometry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 3E4C8
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene ATG13
Gene Accession No. O75143
Gene Alias 1110053A20Rik; Atg13; ATG13 autophagy related 13 homolog; autophagy related 13; autophagy-related protein 13; D2Ertd391e; FLJ20698; Harbi1; Harbi1l; harbinger transposase derived 1; KIAA0652; OTTHUMP00000233321; OTTHUMP00000233322; OTTHUMP00000233323; OTTHUMP00000233324; OTTHUMP00000233325; OTTHUMP00000233326; PARATARG8; RGD1310685
Gene Symbols ATG13
Host Species Mouse
Immunogen Purified recombinant fragment of human ATG13 (AA: 339-550) expressed in E. coli.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9776
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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