ATG13 Monoclonal Antibody (OTI1B1), TrueMAB™, OriGene

Catalog No.	Quantity
50-168-3176	100 μL

Catalog No. 50-168-3176 Supplier OriGene Supplier No. TA810065

Description

Mouse Monoclonal Antibody

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1. ATG13 forms a complex with ULK1 and ULK2, the mammalian homologs of ATG1, and with FIP200. This complex is a target of TOR phosphorylation under normal conditions; inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1 and ULK2, which then leads to autophagy. Knockdown of ATG13 inhibits autophagosome formation.

Specifications

• Antigen: ATG13
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI1B1
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: ATG13
• Gene Accession No.: O75143
• Gene Alias: KIAA0652, PARATARG8
• Gene Symbols: ATG13
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 285-364 of human ATG13 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 9776
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1