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Invitrogen™ ATM Polyclonal Antibody, DyLight™ 488
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Catalog No. PIPA522690
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PIPA522690 50 μL
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Catalog No. PIPA522690 Supplier Invitrogen™ Supplier No. PA522690
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Description

Rabbit Polyclonal Antibody

ATM Polyclonal Antibody for Western Blot, IHC (P), ICC/IF, Flow, ELISA, IP

Ataxia-telangiectasia Mutated (ATM) is a protein that belongs to the PI3/PI4 kinase family. Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and an increased risk of lymphoid cancer. The ATM gene codes for a protein belonging to the phosphoinositide 3-kinase (PI3K) superfamily. ATM phosphorylates proteins instead of lipid and has many downstream targets that act as cell-cycle regulators including: P53, Mdm2, BRCA1, and SMC1. The ATM protein is responsible for repairing double-stranded DNA breaks that occur because of ionizing radiation and other mutagens. The ATM's C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Studies have shown that ATM becomes autophosphorylated and upregulated by exposure to ionizing radiation. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction. Further, DNA damage caused by ionizing irradiation activates ATM-kinase, leading to a cascade of kinase reactions that regulate cell cycle, apoptosis, and DNA damage repair. Studies have linked ATM to apoptosis along with Nbs1 and Chk2 in the E2F1 pathway.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ATM
Applications ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.88 mg/mL
Conjugate DyLight 488
Formulation 50mM sodium borate with 0.05% sodium azide
Gene ATM
Gene Accession No. Q13315, Q62388
Gene Alias AI256621; AT mutated; A-T mutated; A-T mutated homolog; AT mutated protein; AT1; ATA; Ataxia t; Ataxia telangiectasia gene mutated in human beings; ataxia telangiectasia mutated; Ataxia telangiectasia mutated homolog; ATC; ATD; ATDC; ATE; Atm; ATM serine/threonine kinase; C030026E19Rik; DKFZp781A0353; EC 2.7.1.37; MGC74674; serine-protein kinase ATM; TEL1; TEL1, telomere maintenance 1, homolog; TELO1
Gene Symbols ATM
Host Species Rabbit
Immunogen A fragment of the human ATM protein corresponding to the C-terminus (within the last third of the protein sequence).
Purification Method Antigen affinity chromatography
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11920, 300711, 472, 479450
Target Species Human, Mouse, Rat, Canine, Marsupial
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG
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