Invitrogen™ ATP1A2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120239

Catalog No. PIPA5120239

Description

Positive test controls include: U-87MG, OVCAR3, Mouse heart, Mouse lung, Mouse testis, Rat heart. The target is usually found in the following locations: Cell membrane, Membrane, Multi-pass membrane protein. Immunogen sequence: MGRGAGREYS PAATTAENGG GKKKQKEKEL DELKKEVAMD DHKLSLDELG RKYQVDLSKG LTNQRAQDVL.

Atp1a2 encodes an Na+/K+ ATPase, which is a membrane protein that is composed of two subunits - alpha and beta. The Na+/K+ ATPase pump maintains an essential electrochemical gradient within cells through the active transport of sodium (Na+) and potassium (K+) ions. The Atp1a2 encoded protein belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These ion gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. The ATPase enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta), and the catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. The Atp1a2 gene encodes an alpha 2 subunit. Mutations in the Atp1a2 gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. Diseases associated with ATP1A2 include Alternating Hemiplegia Of Childhood and Migraine, Familial Hemiplegic, 2.

Specifications

• Antigen: ATP1A2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Atp1a2
• Gene Alias: Atp1a2; Atpa-3; ATPase Na+/K+ transporting alpha 2 polypeptide; ATPase Na+/K+ transporting subunit alpha 2; ATPase, Na+/K+ transporting, alpha 2 polypeptide; ATPase, Na+K+ transporting, alpha 2; AW060654; FHM2; KIAA0778; MHP2; mKIAA0778; Na(+)/K(+) ATPase alpha(+) subunit; Na(+)/K(+) ATPase alpha-2 subunit; Na+/K+ -ATPase alpha 2 subunit; Na+/K+ ATPase, alpha-A(+) catalytic polypeptide; Na+/K+ ATPase, alpha-B polypeptide; RATATPA2; Sodium Potassium ATPase; Sodium pump subunit alpha-2; sodium/potassium-transporting ATPase alpha-2 chain; sodium/potassium-transporting ATPase subunit alpha-2; sodium-potassium ATPase catalytic subunit alpha-2
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 24212, 477, 98660
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.42 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: P06686, P50993, Q6PIE5
• Gene Symbols: Atp1a2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human ATP1A2 (NP_000693.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG