ATP1A3 (middle) Rabbit anti-Human, Polyclonal, Proteintech

Catalog No.	Quantity
50-173-5807	150 μL

Catalog No. 50-173-5807 Supplier Proteintech Group Inc Supplier No. 280301AP150UL

Description

Rabbit Polyclonal Antibody

This antibody is generated against the middle region (378-580aa) of ATP1A3 and detects 113 kDa protein in SDS-PAGE.

The sodium/potassium ATPase is an integral membrane enzyme found in all cells of higher organisms and is responsible for the ATP-dependent transport of sodium and potassium across the cell membrane. This membrane-bound enzyme is related to a number of other ATPases including sarcoplasmic and endoplasmic reticulum calcium ATPase (SERCA) and plasma membrane calcium ATPase (PMCA). The sodium/potassium ATPase consists of a large, multipass, transmembrane catalytic subunit, termed the alpha subunit, and an associated smaller glycoprotein, termed the beta subunit. Studies indicate that there are three isoforms of the alpha subunit (alpha 1, alpha 2, alpha 3) and two isoforms of the beta subunit (beta 1 and beta 2) encoded by two multigene families. The different isoforms of the sodium/potassium ATPase exhibit tissue-specific and developmental patterns of expression. The alpha 1 and beta mRNAs are present in all cell types examined, whereas the alpha 2 and alpha 3 mRNAs exhibit a more restricted pattern of cell-specific expression. The alpha-3 subunit has been found in neuronal and to skeletal and cardiac muscle, lung and stomach tissues.

Specifications

• Antigen: ATP1A3 (middle)
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 0.27 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene: ATP1A3
• Gene Accession No.: P13637
• Gene Alias: ATP1A3, DYT12, RDP, Sodium pump subunit alpha 3
• Gene Symbols: ATP1A3
• Host Species: Rabbit
• Immunogen: ATP1A3 (middle) Fusion Protein Ag27705
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 478
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG