Invitrogen™ ATP6AP1 Monoclonal Antibody (3H11B12)

Catalog No.	Quantity
FERMA548381	100 μg

Catalog No. FERMA548381 Supplier Invitrogen™ Supplier No. MA548381

Description

Mouse Monoclonal Antibody

ATP6AP1 Monoclonal Antibody for Western Blot, Flow, ELISA

Vacuolar-type H+-ATPase (V-ATPase) is a multisubunit enzyme responsible for acidification of eukaryotic intracellular organelles. V-ATPases pump protons against an electrochemical gradient, thereby synthesizing ATP. A peripheral V1 domain, which is responsible for ATP hydrolysis, and an integral V0 domain, which is responsible for proton translocation, compose the V-ATPase. Nine subunits (A-H) make up the V1 domain and five subunits (a, d, c, c' and c) make up the V0 domain. ATP6AP1 (ATPase, H+ transporting, lysosomal accessory protein 1), also known as 16A, CF2, Ac45, XAP3, ATP6S1, VATPS1 (vacuolar ATP synthase S1 accessory protein) or ATP6IP1, is a type I transmembrane, V-ATPase accessory protein that is predominantly expressed in endocrine and neuronal cells. ATP6AP1 is responsible for targeting the V-ATPase enzyme to specialized complex vacuolar systems. Via its cytoplasmic tail, ATP6AP1 interacts with subunits of the V0 domain. The disruption of this interaction in osteoclasts results in impaired bone resorption, suggesting an important role for ATP6AP1 in proper osteoclastic bone resorption.

Specifications

• Antigen: ATP6AP1
• Applications: ELISA, Flow Cytometry, Western Blot
• Classification: Monoclonal
• Clone: 3H11B12
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% sodium azide
• Gene: ATP6AP1
• Gene Accession No.: Q15904
• Gene Alias: 16A; Ac45; AI316502; Atp6ap1; ATP6IP1; Atp6s1; ATPase H+ transporting accessory protein 1; ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1; ATPase, H+ transporting, lysosomal accessory protein 1; ATPase, H+ transporting, lysosomal interacting protein 1; AW108110; C7-1; C7-1 protein; CF2; H-ATPase subunit; mFLJ00383; MGC129781; protein C7-1; Protein XAP-3; vacuolar H+ ATPase accessory subunit 1; vacuolar proton pump subunit S1; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; V-ATPase subunit Ac45; V-ATPase subunit S1; VATPS1; V-type proton ATPase subunit S1; XAP3; XAP-3
• Gene Symbols: ATP6AP1
• Host Species: Mouse
• Immunogen: Purified recombinant fragment of human ATP6AP1 (AA: 51-151) expressed in E. Coli.
• Purification Method: Protein G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 537
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1