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Invitrogen™ ATP8A2 Polyclonal Antibody
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Catalog No. PIPA565256
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100 μL
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PIPA565256 100 μL
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Catalog No. PIPA565256 Supplier Invitrogen™ Supplier No. PA565256
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: GVTYGHFPELA REPSSDDFCR MPPPCSDSCD FDDPRLLKNI EDRHPTAPCI QEFLTLLAVC HTVVPEKDGD N Highest antigen sequence identity to the following orthologs - mouse 88%, rat 89%.

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Involved in regulation of neurite outgrowth; acting in synergy with TMEM30A. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ATP8A2
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ATP8A2
Gene Accession No. Q9NTI2
Gene Alias ATP; ATP8A2; ATPase class I type 8A member 2; ATPase phospholipid transporting 8A2; ATPase, aminophospholipid transporter, class I, type 8A, member 2; ATPase, aminophospholipid transporter-like, class I, type 8A, member 2; ATPIB; CAMRQ4; IB; ML-1; P4-ATPase flippase complex alpha subunit ATP8A2; Phospholipid-transporting ATPase IB; probable phospholipid-transporting ATPase IB
Gene Symbols ATP8A2
Host Species Rabbit
Immunogen Recombinant Human ATP8A2. Recombinant protein control fragment (Product #RP-105975).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51761
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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