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Invitrogen™ ATR Polyclonal Antibody
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Catalog No. PA1450
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100 μL
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PA1450 100 μL
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Catalog No. PA1450 Supplier Invitrogen™ Supplier No. PA1450
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Description

Rabbit Polyclonal Antibody

PA1-450 detects ATR (Ataxia Telangiectasia Mutated (ATM) and Rad3-related protein) from human cells. PA1-450 has been successfully used in Western blot immunofluoresence and immunoprecipitation procedures. By Western blot, this antibody detects an ~305 kDa protein representing ATR in lysate from UV irradiated K562 cells. PA1-450 antigen is a fusion protein corresponding to amino acid residues 400-460 from human ATR.

The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ATR
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 4 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene ATR
Gene Accession No. Q13535
Gene Alias 2310008J16Rik; 2810405N18Rik; ataxia telangiectasia and Rad3 related; ataxia telangiectasia and Rad3-related protein; ATR; ATR serine/threonine kinase; EC 2.7.11.1; FCTCS; FRAP-related protein 1; FRAP-related protein-1; FRP1; I79_000761; kinase ATR; MEC1; MEC1, mitosis entry checkpoint 1, homolog; protein kinase ATR; SCKL; SCKL1; Serine/threonine-protein kinase ATR; TEM8
Gene Symbols ATR
Host Species Rabbit
Immunogen Fusion protein containing residues 400-460 of the human ATR protein.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 545
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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