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Invitrogen™ ATR Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA1450

Catalog No. PA1450


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Description

Description

PA1-450 detects ATR (Ataxia Telangiectasia Mutated (ATM) and Rad3-related protein) from human cells. PA1-450 has been successfully used in Western blot immunofluoresence and immunoprecipitation procedures. By Western blot, this antibody detects an ~305 kDa protein representing ATR in lysate from UV irradiated K562 cells. PA1-450 antigen is a fusion protein corresponding to amino acid residues 400-460 from human ATR.

The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

ATR
Polyclonal
Unconjugated
ATR
2310008J16Rik; 2810405N18Rik; ataxia telangiectasia and Rad3 related; ataxia telangiectasia and Rad3-related protein; ATR; ATR serine/threonine kinase; EC 2.7.11.1; FCTCS; FRAP-related protein 1; FRAP-related protein-1; FRP1; I79_000761; kinase ATR; MEC1; MEC1, mitosis entry checkpoint 1, homolog; protein kinase ATR; SCKL; SCKL1; Serine/threonine-protein kinase ATR; TEM8
Rabbit
Affinity Chromatography
RUO
545
-20°C, Avoid Freeze/Thaw Cycles
Liquid
Immunoprecipitation, Western Blot
4 mg/mL
PBS with 0.05% sodium azide
Q13535
ATR
Fusion protein containing residues 400-460 of the human ATR protein.
100 μL
Primary
Human
Antibody
IgG
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