ATRX Polyclonal Antibody, Active Motif™

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-199-3091	Active Motif 61050	10 μL
50-199-3090	Active Motif 61049	100 μL

Description

ATRX encodes a protein that contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Specifications

• Antigen: ATRX
• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: P46100
• Gene ID (Entrez): 546
• Immunogen: This ATRX antibody was raised against a peptide within the C-terminus of human ATRX.
• Primary or Secondary: Primary
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Gene: ATRX

• Concentration: Lot-Specific
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: 70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
• Gene Alias: 4833408C14Rik; AI447451; alpha thalassemia/mental retardation syndrome (X-linked); alpha thalassemia/mental retardation syndrome X-linked; alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae); alpha thalassemia/mental retardation syndrome X-linked homolog; alpha thalassemia/mental retardation syndrome X-linked homolog (human); ATP-dependent helicase ATRX; ATR2; Atrx; ATRX, chromatin remodeler; DNA dependent ATPase and helicase; DXHXS6677E; helicase 2; helicase 2, X-linked; helicase II; Heterochromatin protein 2; HP1 alpha-interacting protein; Hp1bp2; Hp1bp38; HP1-BP38; HP1-BP38 protein; JMS; mental retardation, X-linked 52; MRX52; MRXHF1; MRXS3; pABP-2; RAD54; RAD54L; RP5-875J14.1; SFM1; SHS; Transcriptional regulator ATRX; XH2; X-linked helicase II; X-linked nuclear protein; Xnp; Zinc finger helicase; Znf-HX
• Gene Symbols: ATRX
• Isotype: IgG
• Purification Method: Antigen affinity chromatography
• Product Type: Antibody