ATXN7L2 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-8175	100 μL

Catalog No. 50-198-8175 Supplier Bioss Supplier No. BS7976R

Description

Rabbit Polyclonal Antibody

SCA7 is an autosomal dominant neurodegenerative disorder characterized by ataxia and selective neuronal cell loss caused by the expansion of a translated CAG repeat encoding a polyglutamine tract in ataxin-7, which is the SCA7 gene product. Ataxin-7 is a nuclear protein that is expressed within neurons both affected and unaffected in SCA7 pathology with subcellular localization being variable depending upon the neuronal subtype. Polyglutamine expanded in ataxin-7 may carry out its pathogenic effects in the nucleus by altering the matrix-associated nuclear structure and/or by disrupting nucleolar function.ATXN7L2 (Ataxin-7-like protein 2) is a 722 amino acid protein that contains a SCA7 domain, which is highly conserved through all members of the ATXN7 gene family. The gene encoding ATXN7L2 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome.

Specifications

• Antigen: ATXN7L2
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: ATXN7L2
• Gene Accession No.: Q5T6C5
• Gene Alias: 2610528J18Rik; ataxin 7 like 2; ataxin 7-like 1; ataxin 7-like 2; Ataxin-7-like protein 2; ATXN7L2; mFLJ00381 protein; RGD1307047
• Gene Symbols: ATXN7L2
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human ATXN7L2.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 127002
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG