Invitrogen™ ATXN7L3 Monoclonal Antibody (2ATX-2B1)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA3084

Catalog No. PIMA3084

Description

MA3-084 detects Ataxin 7L3 from human and mouse samples. MA3-084 has been successfully used in Western blot, immunofluorescence, and ELISA applications.

Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B (PubMed:18206972, PubMed:21746879). The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex (PubMed:18206972). Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B (PubMed:27601583). [UniProt].

Specifications

• Antigen: ATXN7L3
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: Ascites with 0.05% sodium azide
• Gene Accession No.: A2AWT3, Q14CW9
• Gene Symbols: ATXN7L3
• Immunogen: Synthetic Peptide coupled to Ovalbumin corresponding to aa 278 to aa 296 of human ataxin 7L3.
• Regulatory Status: RUO
• Gene ID (Entrez): 217218, 56970
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Clone: 2ATX-2B1
• Conjugate: Unconjugated
• Gene: ATXN7L3
• Gene Alias: AT7L3; ataxin 7 like 3; ataxin 7-like 3; ataxin-7-like protein 3; ATXN7L3; DKFZp761G2113; E030022H21Rik; SAGA-associated factor 11 homolog
• Host Species: Mouse
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG1 κ