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Invitrogen™ ATXN7L3 Monoclonal Antibody (2ATX-2B1)
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Catalog No. PIMA3084
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PIMA3084 50 μL
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Catalog No. PIMA3084 Supplier Invitrogen™ Supplier No. MA3084
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Description

Mouse Monoclonal Antibody

MA3-084 detects Ataxin 7L3 from human and mouse samples. MA3-084 has been successfully used in Western blot, immunofluorescence, and ELISA applications.

Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B (PubMed:18206972, PubMed:21746879). The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex (PubMed:18206972). Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B (PubMed:27601583). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen ATXN7L3
Applications Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 2ATX-2B1
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Ascites with 0.05% sodium azide
Gene ATXN7L3
Gene Accession No. A2AWT3, Q14CW9
Gene Alias AT7L3; ataxin 7 like 3; ataxin 7-like 3; ataxin-7-like protein 3; ATXN7L3; DKFZp761G2113; E030022H21Rik; SAGA-associated factor 11 homolog
Gene Symbols ATXN7L3
Host Species Mouse
Immunogen Synthetic Peptide coupled to Ovalbumin corresponding to aa 278 to aa 296 of human ataxin 7L3.
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 217218, 56970
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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