Tocris Bioscience™ AUNP 12

Description

Peptide inhibitor of the PD-1 signaling pathway

AUNP 12 is an immune checkpoint modulator targeting the programmed cell death 1 (PD-1) signaling pathway. It inhibits the interaction between PD-1 and its ligands, PD-L1 and PD-L2. In the mouse splenocyte assay system, AUNP 12 rescues proliferation (EC50 values are 17 and 16 nM for PD-L1 and PD-L2, respectively) and enhances T-cell activity by restoring IFNγ release inhibited by PD-L1 and PD-L2 (EC50 values are 49 nM and 51 nM respectively). In a mouse Renca renal cell carcinoma model, AUNP 12 shows an additive antitumor effect when combined with Cyclophosphamide (Cat. No. 4091).

Specifications

• Gene ID (Entrez): 5133
• Purity: 95%
• CAS: 1353563-85-5
• Content And Storage: Store at -20°C
• Gene Alias: B7-DC, B7H1, B7-H1, Butyrophilin-like Protein, CD273, CD274, CD279, CD279 antigen, hPD-1, IFG, IFI, IFNG, IFNgamma, PD1, PD1hPD-l, PDCD1, PDCD1L1, PDCD1LG1, PDCD1LG2, PDL1, PDL2, programmed cell death 1, programmed cell death protein 1, Protein PD-1, SLEB2
• Molecular Weight (g/mol): M.W. (Observed): 3261.56
• Quantity: 1 mg