Thermo Scientific Chemicals Aurora Kinase/Cdk Inhibitor

Description

 

Aurora Kinase/Cdk Inhibitor is a broad spectrum inhibitor of cyclin-dependent kinases and aurora kinases including CDK1/Cyclin B, CDK2/Cyclin A, CDK2/Cyclin E, Aurora-A and Aurora-B. It as been shown to induce growth suppression and mitotic defects, these results suggest that Aurora Kinase/Cdk Inhibitor could be useful for cell cycle analysis and therapy of various cancers, including Ewing's sarcoma.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Specifications

Chemical Identifiers

• CAS: 443797-96-4
• Molecular Formula: C15H12F2N6O3S.CH3CN, C15H12F2N6O3S
• Molecular Weight (g/mol): 394.36
• InChI Key: KDKUVYLMPJIGKA-UHFFFAOYSA-N
• Synonym: 4-(5-Amino-1-(2,6-difluorobenzoyl)-1H-[1,2,4]triazol-3-ylamino)-benzenesulfonamide;
• IUPAC Name: 4-{[5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino}benzene-1-sulfonamide
• SMILES: NC1=NC(NC2=CC=C(C=C2)S(N)(=O)=O)=NN1C(=O)C1=C(F)C=CC=C1F

• Quantity: 5 mg
• Description: White
• Content And Storage: 2°C to 8°C
• For Use With (Application): A cell-permeable triazolylsulfonamido compound that acts a reversible, ATP-competitive kinase inhibitor with selectivities towards Aurora kinases
• Formula Weight: 435.41
• Sensitivity: Light Sensitive
• Solubility: Soluble in DMSO at 15mg/ml
• Product Type: Aurora Kinase/Cdk Inhibitor
• Form: Powder

Safety and Handling

Recommended Storage

Keep cold; Store under Argon

SDS

RUO – Research Use Only