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Apexbio Technology LLC Avermectin B1a 65195-55-3 5mg
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Supplier:  Apexbio Technology LLC A32035

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Avermectin B1a (65195-55-3) is a macrocyclic lactone compound targeting -aminobutyric acid (GABA)-gated chloride channels It is designed to modulate these channels thereby inducing neuronal hyperpolarization and neuromuscular paralysis Avermectin B1a exerts its biological activity primarily through promoting chloride ion influx and inhibiting synaptic transmission in nematodes Experimental evidence shows that Avermectin B1a enhances binding of benzodiazepines (e g flunitrazepam) at GABA receptors with an EC50 approximately 50-fold lower compared to GABA Based on these pharmacological properties Avermectin B1a holds research potential in studies on anthelmintic and insecticidal mechanisms

Catalog No. 50-000-94535


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