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Invitrogen™ AXIN2 Polyclonal Antibody
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Catalog No. PIPA521093
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100 μg
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Catalog No. Quantity
PIPA521093 100 μg
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Catalog No. PIPA521093 Supplier Invitrogen™ Supplier No. PA521093
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Description

Rabbit Polyclonal Antibody

A suggested positive control is mouse lung tissue lysate. PA5-21093 can be used with blocking peptide PEP-1207.

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
TRUSTED_SUSTAINABILITY

Specifications

Antigen AXIN2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene AXIN2
Gene Accession No. O70240, O88566, Q9Y2T1
Gene Alias Axi1; axil; axin 2; Axin like protein; axin2; axin-2; Axin-like protein; Axis inhibition protein 2; conductin; DKFZp781B0869; MGC10366; MGC126582; ODCRCS
Gene Symbols AXIN2
Host Species Rabbit
Immunogen A 20 amino acid peptide near the carboxy terminus of human AXIN2.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12006, 29134, 8313
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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