Invitrogen™ AXIN2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA521093

Catalog No. PIPA521093

Description

A suggested positive control is mouse lung tissue lysate. PA5-21093 can be used with blocking peptide PEP-1207.

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

Specifications

• Antigen: AXIN2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: AXIN2
• Gene Alias: Axi1; axil; axin 2; Axin like protein; axin2; axin-2; Axin-like protein; Axis inhibition protein 2; conductin; DKFZp781B0869; MGC10366; MGC126582; ODCRCS
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12006, 29134, 8313
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: O70240, O88566, Q9Y2T1
• Gene Symbols: AXIN2
• Immunogen: A 20 amino acid peptide near the carboxy terminus of human AXIN2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov