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Invitrogen™ AXIN2 Recombinant Rabbit Monoclonal Antibody (JM11-30)
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Catalog No. PIMA532646
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PIMA532646 100 μL
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Catalog No. PIMA532646 Supplier Invitrogen™ Supplier No. MA532646
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Description

Rabbit Recombinant Monoclonal Antibody

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
TRUSTED_SUSTAINABILITY

Specifications

Antigen AXIN2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunohistochemistry, Western Blot
Classification Recombinant Monoclonal
Clone JM11-30
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide; pH 7.4
Gene AXIN2
Gene Accession No. O70240, O88566, Q9Y2T1
Gene Alias Axi1; axil; axin 2; Axin like protein; axin2; axin-2; Axin-like protein; Axis inhibition protein 2; conductin; DKFZp781B0869; MGC10366; MGC126582; ODCRCS
Gene Symbols AXIN2
Host Species Rabbit
Immunogen Synthetic peptide within Human Axin2 aa 55-93.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12006, 29134, 8313
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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