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  5. Tocris Bioscience™ AZD 9291

Tocris Bioscience™ AZD 9291

Catalog No. 887350
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Catalog No. Quantity
88-735-0 50 mg
88-731-0 10 mg
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Catalog No. 88-735-0 Supplier Tocris Bioscience™ Supplier No. 8873/50
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Description

Potent mutant-selective EGFR inhibitor

AZD 9291 is a potent mutant-selective EGFR inhibitor (IC50 values are 1 and 12 nM against EGFR mutants L858R/T790M and L858R, respectively). AZD 9291 exhibited nearly 200 times greater potency against L858R/T790M than wild-type EGFR. In vivo, AZD 9291 causes tumor regression in mutant EGFR xenograft models of non-small cell lung cancer (NSCLC) and transgenic mutant T790M EGFR disease models. AZD 9291 is orally bioavailable.

Specifications

Chemical Name or Material N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide
CAS 1421373-65-0
Quantity 50 mg
Target EGF Receptor Inhibitors
Molecular Formula C28H33N7O2
Purity 98%
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