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Invitrogen™ B-Raf Recombinant Rabbit Monoclonal Antibody (SU34-04)
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Catalog No. PIMA542429
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100 μL
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PIMA542429 100 μL
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Catalog No. PIMA542429 Supplier Invitrogen™ Supplier No. MA542429
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Description

Rabbit Recombinant Monoclonal Antibody

Positive Control: Rat brain tissue, human placenta tissue, human pancreas tissue, mouse fallopian tube tissue, mouse brain tissue, Hela. Subcellular Location: Nucleus, Cytoplasm, Cell membrane.

BRAF is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It is activated by somatic point mutation in human cancer, and is thought to play a role in the postsynaptic responses of hippocampal neuron. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in B-Raf have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for B-Raf.
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Specifications

Antigen B-Raf
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Recombinant Monoclonal
Clone SU34-04
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 40% glycerol, 0.05% BSA and 0.05% sodium azide; pH 7.4
Gene BRAF
Gene Accession No. P15056, P28028
Gene Alias 94 kDa B-raf protein; 9930012E13Rik; AA120551; AA387315; AA473386; Braf; B-raf; B-raf protein; B-raf protein isoform 1; B-raf protein isoform 2; B-Raf proto-oncogene serine/threonine-protein kinase; B-Raf proto-oncogene serine/threonine-protein kinase (p94); B-Raf proto-oncogene, serine/threonine kinase; Braf transforming gene; BRAF1; B-RAF1; Braf2; Braf-2; C230098H17; C87398; C-RMIL; D6Ertd631e; FLJ95109; MGC126806; murine sarcoma viral (v-raf) oncogene homolog B1; NS7; p94; Proto-oncogene B-Raf; proto-oncogene c-Rmil; RAFB1; RMIL; rmil serine/threonine-protein kinase; serine/threonine kinase; serine/threonine-protein kinase B-raf; Serine/threonine-protein kinase Rmil; v-raf murine sarcoma viral oncogene homolog B; v-raf murine sarcoma viral oncogene homolog B1
Gene Symbols BRAF
Host Species Rabbit
Immunogen Synthetic peptide within human B Raf aa 60-100.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 109880, 114486, 673
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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