Invitrogen™ B4GALT1 Polyclonal Antibody

Catalog No.	Quantity
PIPA5117336	100 μL

Catalog No. PIPA5117336 Supplier Invitrogen™ Supplier No. PA5117336

Description

Rabbit Polyclonal Antibody

Centrifuge briefly prior to opening.

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing.

Specifications

• Antigen: B4GALT1
• Applications: Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1.03 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene: B4GALT1
• Gene Accession No.: P15291
• Gene Alias: b1,4-Galactosyltransferase I; B-1,4-GalT; B-1,4-GalT1; B4galt1; b4Gal-T1; Beta-1,4-galactosyltransferase 1; beta-1,4-GalT; beta-1,4-GalT1; beta-1,4-GalTase 1; beta4Gal-T1; Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase; Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase; CDG2D; galactosyltransferase 2 beta 1, 4; GalT; Ggtb; GGTB2; glycoprotein galactosyltransferase beta 1, 4; glycoprotein-4-beta-galactosyltransferase 2; Golgi complex; GT1; GTB; lactose synthase; Lactose synthase A protein; N-acetyllactosamine synthase; Nal synthase; Processed beta-1; Processed beta-1,4-galactosyltransferase 1; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1
• Gene Symbols: B4GALT1
• Host Species: Rabbit
• Immunogen: Recombinant protein encompassing a sequence within the center region of human B4GALT1. The exact sequence is proprietary.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2683
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG